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A wide range of urease inhibitors of different structural families are known. Inhibition of urease is not only of interest to agriculture, but also to medicine as pathogens like H. pylori produce urease as a survival mechanism. Known structural classes of inhibitors include:cite-ref-34[34]cite-ref-35[35]

• Analogues of urea, the strongest being thioureas like 1-(4-chlorophenyl)-3-palmitoylthiourea.

• Phosphoramidates, the most commonly used in agriculture (see above).

• Hydroquinone and quinones. In medicine, the most interesting are quinolones, already a class of widely used antibiotics.

• Some plant metabolites are also urease inhibitors, an example being allicin. These have potential both as environmentally-friendly fertilizer additivescite-ref-36[36] and natural drugs.

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